OUR SCIENCE

Formulation Philosophy

Calizor is built on the principle that effective clear skin support requires addressing multiple biological pathways simultaneously.

Why a Multi-Pathway Approach

Skin health is multifactorial — hormonal balance, sebum production, barrier integrity, and oxidative stress all contribute, and supporting only one of them tends to leave gaps. Calizor’s formulation is built around three interconnected nutritional pathways.

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Hormonal Modulation

Androgen and estrogen balance influence sebum production and vascular reactivity in skin. Nutrients such as Vitamin B6 and Zinc support the body's normal hormone metabolism and inflammatory signaling, helping maintain balance upstream of skin oil production.
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Inflammatory Response

Cytokine signaling governs how skin tissue responds to everyday stressors. Niacinamide (B3) and Curcumin support a balanced inflammatory response through their published roles in NF-κB signaling and interleukin regulation.
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Antioxidant Support

Oxidative stress places a continuous burden on skin structures. Quercetin, Zinc, and Copper support layered antioxidant defense — helping scavenge free radicals, supporting superoxide dismutase activity, and helping maintain cell membrane stability.

RESEARCH

Research Highlights

Vitamin B6 (Pyridoxal 5-Phosphate) and Hormonal Balance in Skin

Vitamin B6 (as pyridoxal 5-phosphate) acts as a coenzyme in steroid hormone metabolism, a pathway that influences sebaceous gland activity and skin oil balance.

Journal of Clinical Endocrinology & Metabolism, 2017

Zinc and the Skin Inflammatory Response

Zinc participates in immune signaling and sebaceous gland regulation, and adequate zinc status is associated with a balanced inflammatory response in skin tissue.

Dermatologic Therapy, 2018

Curcumin and Oxidative Stress in Skin

Curcumin supports the skin's antioxidant capacity through its published role in reactive oxygen species regulation and NF-κB–mediated signaling.

Phytotherapy Research, 2020